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Cancer Molecular Biology for Targeted Radiotherapeutics - Research Assistant Professor
University of Tennessee, Knoxville
Application
Details
Posted: 03-Jul-25
Location: Knoxville, TN
Internal Number: 169857
This position is a component of the University of Tennessee - Oak Ridge Innovation institute?s (UT-ORII) Development and Advancement of Radiopharmaceutical Therapies (DART) Convergent Research Initiative (CRI). This position will reside at the University of Tennessee, Knoxville (UTK) and have regular collaborations with and visits to Oak Ridge National Laboratory (ORNL) as well as collaborations with researchers at UT Health Science Center, Memphis. The position's faculty appointment will be with UT-ORII at the University of Tennessee, Knoxville, situated in close collaboration with the UTK Biochemistry & Cellular and Molecular Biology department (BCMB).
Roles and Responsibilities
The hired researcher will become part of a growing network of collaborators across UTK, ORNL, and the University of Tennessee Health Science Center that is working to advance the development of targeted alpha-radiation therapy of solid tumors. The hired researcher will investigate molecular and cellular pathways in cancer that can be exploited for targeting and/or to study the downstream effects of radiotherapy on cells.
We are particularly interested in researchers with experience and future research goals in one of the following areas:
Identifying cancer specific signatures that could be exploited for targeting
Genomics (especially single cell genomics) of cancer
DNA damage and repair pathways in cancer
Molecular / biochemical characterization of potential therapeutic targets
Cancer organoids or tumor microenvironment co-cultures for evaluation of candidate therapeutics
Assays that will measure the impact of radiotherapeutics on cells and tissues (microscopy, genomics/proteomics, molecular pathways, DNA damage, etc.)
The hired research faculty will collaborate on DART research projects, proposal preparation, submission, and student mentoring at the graduate level. This 12-month, non-tenure track position is a five-year contract with full salary support for the first year, followed by a gradual decrease in salary coverage such that the successful applicant will receive 50% salary support in year 5 and is expected to receive extramural funding by year 3 or earlier. The applicant will be expected to recruit graduate students (from the interdisciplinary Genome Science and Technology Program) by year 3. A competitive startup package including support for PhD students and budget for equipment will be offered, and anchor investigators in this CRI will provide mentoring to the hire.
Key Responsibilities:
The selected candidate will:
Develop and lead research studies to study molecular and cellular pathways in cancer that could be targeted with radiotherapeutics and/or the downstream effects of radiotherapy on cellular systems.
Develop a strong collaboration with the members of this CRI at UTK, UTHSC, and ORNL, as well as with other investigators in the BCMB department.
Develop applications for extramural funding.
Present findings to peer groups at conferences and at UT-ORII meetings.
Adviseand supervise graduatestudents.
Required:
PhD in a field related to the molecular and cellular biology of cancer.
A trackrecordof relevant peer-reviewedpublications relevant areas.
Strong communication skills and an ability to collaborate with other researchers and advise graduate students.
Preferred Qualification:
Track record in developing grant proposals and securing funding.
A path to independence as a researcher is desired, though an ?on-ramp? through collaboration with more senior investigators is also encouraged.
Additional Information
This is a 12-month, non-tenure track position.
The appointment will be with the University of Tennessee, Knoxville.
The primary work location is the University of Tennessee campus in Knoxville, but it may also include visits to collaborator sites on the campuses of ORNL and UTK.
The position will be implemented as an initial three-year contract with full salary support for the first year, followed by a gradual increase in expected external salary funding in subsequent years.
The applicant will be expected to recruit graduate students by year three.
A competitive startup package, including funds for graduate students and equipment, will be offered.
Salary and title/rank will be determined commensurate with experience.
Benefits will be typical of exempt employees at the University of Tennessee.
The candidate must be eligible for initial clearance at Oak Ridge National Laboratory.
Facilities and Environment at the University of Tennessee
The candidate will have laboratory space in the modern Ken and Blaire Mossman building, which houses high-level research and instructional space. There are core facilities and shared instrumentation for BSL-2 cell culture, next-generation sequencing, associated high-performance computation, flow cytometry, advanced microscopy, a vivarium which will be equipped with an X-ray irradiator and PET-CT, and a bioanalytical resource facility https://bcmb.utk.edu/research/bioanalytical-resource-facility/ .
The successful candidate will also have opportunities to collaborate with a diverse set of colleagues in BCMB, Microbiology, and Nutrition, as well as at the UT Ag-Vet campus, the UT Medical Center, and the National Institute for Modeling Biological Systems.
Review of applications will begin on July 15, 2025 and will continue until the position is filled. All application materials must be submitted in Interfolio at http://apply.interfolio.com/169857
Applications must include:
a letter of interest, explaining the candidate?s experience in one of the desired areas;
a comprehensive curriculum vitae;a 3-page researchplan;
The University of Tennessee-Oak Ridge Innovation Institute was launched by the University of Tennessee and Oak Ridge National Laboratory in 2021, in response to America?s need for a stronger pool of science, technology, engineering and mathematics, and increasingly life science talent.
UT-ORII is leveraging UT and ORNL?s best capabilities and resources to accelerate collaborative discovery, innovation and interdisciplinary graduate education; and to prepare the next generation of talent in areas of critical importance to the nation and the State of Tennessee. The institute?s current convergent research areas include clean manufacturing and advanced materials, energy storage, transportation, radiopharmaceuticals, and circular bioeconomies. To learn more about UT-ORII visit utorii.com.
All qualified applicants will receive equal consideration for employment and admission without regard to race, color, national origin, religion, sex, pregnancy, marital status, sexual orientation, gender identity, age, physical or mental disability, genetic information, veteran status, and parental status, or any other characteristic protected by federal or state law. In accordance with the requirements of Title VI of the Civil Rights Act of 1964, Title IX of the Education Amendments of 1972, Section 504 of the Rehabilitation Act of 1973, and the Americans with Disabilities Act of 1990, the University of Tennessee affirmatively states that it does not discriminate on the basis of race, sex, or disability in its education programs and activities, and this policy extends to employment by the university.
Requests for accommodation of a disability should be directed to the ADA Coordinator at Equal Opportunity and Accessibility, 1840 Melrose Avenue, Knoxville, TN 37996-3560, by email to eoa@utk.edu, or by phone at 865-974-2498. Inquiries and charges of violation of Title VI (race, color, and national origin), Title IX (sex), Section 504 (disability), the ADA (disability), the Age Discrimination in Employment Act (age), sexual orientation, or veteran status should be directed to the Office of Investigation and Resolution, 216 Business Incubator Building, E J. Chapman Drive, Knoxville, TN 37996-3560, by email to investigations@utk.edu, or by phone at 865-974-0717.
Our primary mission is to move forward the frontiers of human knowledge and enrich and elevate the citizens of the state of Tennessee, the nation, and the world. As the preeminent research-based, land-grant university in the state, UT embodies the spirit of excellence in teaching, research, scholarship, creative activity, outreach, and engagement attained by the nation’s finest public research institutions.