In this role, you will work under the direct supervision of the PI and will perform computational chemistry experiments. This activity will entail making homology models of proteins, docking ligands into binding sites, parameterizing structures, running molecular dynamics simulations, analyzing trajectories and estimating binding energies. You will interpret the results with regard to protein structure/function and ligand binding. You will be responsible for formulating the exact experimental protocols and writing up the results of the experiments and analyses for publication in scientific journals. You will also be expected to present the results at scientific meetings.
University at Buffalo is an affirmative action/equal opportunity employer and, in keeping with our commitment, welcomes all to apply including veterans and individuals with disabilities.
Ph.D. Degree in Chemistry, Physics, Biophysics or a related field.
Experience in investigating membrane receptors, allosteric proteins and ligand binding sites, and using computational approaches to estimate small ligand binding pathways and free energies. Familiarity with the kinetics of transitions between different conformational states is desirable.
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