Berkeley Lab's Molecular Biophysics & Integrated BioimagingDivision has an opening for a Research Scientist. The Berkeley Synchrotron Infrared Structural Biology (BSISB) Imaging Project is a national and international multidisciplinary research program operated as an infrared imaging technology research & development center, and also a user resource for making groundbreaking discoveries. The Research Scientist will contribute to the planning and development of transformational imaging technologies, in addition to the operation, optimization, maintenance and improvement of the existing research and technology capabilities. The successful candidate will participate in or lead the effort in the technology research and development within the BSISB imaging program as well as engage in high-quality collaborative research, data analysis, and publication activities with external users of the BSISB resource. The candidate is expected to collaborate with scientists and engineers at the Advanced Light Source to develop new capabilities that would accelerate the BSISB's achievement to meet DOE's missions and will be involved in preparing and submitting competitive proposals to external funding agencies and establish new research collaborations.
What You Will Do:
Lead the collaboration with the infrared beamline team at the Advanced Light Source (ALS) to contribute to the successful operation, optimization, maintenance and improvement of the BSISB program imaging technology.
Lead the R&D of super-resolution infrared Fourier ptychographic infrared spectral microscopy and coherent imaging systems for infrared spectral microscopy at the ALS.
Lead the R&D effort of integrating FTIR imaging systems with adaptive optics systems.
Co-Lead computation effort involving collaborations with the computational and data integration teams at the Center for Advanced Mathematics for Energy Research Applications (CAMERA), the Computational Research and Theory (CRT) facility, and at the ALS to upgrade the existing software infrastructure to support new capabilities for infrared spectral data acquisition, visualization, analysis & management, computational imaging and artificial intelligence for hyperspectral image analysis.
Develop new approaches in data processing and interpretation supports
Outreach to new users and provide on-line, telephone and in-person assistance to users with experimental trouble-shooting.
Disseminate results by preparing progress reports in the form of oral presentations (pptx), written progress reports, and especially manuscripts for peer-reviewed publications.
Maintain a close working relationship with the EH&S staff to ensure that all user activities meet the EH&S requirements.
Prepare and submit competitive proposals to external funding agencies and establish new research collaborations.
Present scientific findings at seminars and conferences.
Additional Responsibilities as needed:
Participate in MBIB Division committees and working groups.
Participate in Lab-wide committees and working groups.
Provide support for mammalian cell line tissue culture, maintenance, transfection and biochemical analysis for cell biology research projects and user groups.
What is Required:
Ph.D. in Biophysics, Chemistry, or a related discipline and at least five years of work experience after Ph.D. and/or equivalent overall work experience.
Significant experience in FTIR microscopy, structured illumination microscopy, Fourier ptychography, computational imaging, adaptive optics and other related imaging technology.
Significant experience in multimodal imaging systems.
Strong knowledge and experience of synchrotron FTIR spectromicroscopy as applied to bioenergy, biogeochemistry, biomedicine, and low-dose radiation research.
Proven desire to work in a multidisciplinary technology R&D environment and to integrate with researchers with different backgrounds and skill sets.
Proven significant experience with microfluidic device applications in bioenergy, environmental health, and biomedical research.
Proven excellent experience in signal processing, image processing, multivariate statistics, chemometrics, deep learning and machine learning for spectra & image analysis.
Proven significant experience in high throughput technology as applied to instrumentation development and data analyses.
Proven capabilities to work collaboratively, reporting results internally to fellow researchers through weekly meetings, and externally through conference presentations and peer-reviewed publications.
Proven capabilities to prepare research publications, and communicate results at professional meetings.
Proven capabilities to design, prepare, and implement effectively project goals and milestones.
Proven capabilities in designing and executing alternative and creative solutions to meet project goals.
Proven excellent written and oral communications skills.
Proven excellent people-skills for working in a dynamic team environment.
Additional Desired Qualifications:
General: Proven ability to work outside the established field of expertise.
Data acquisition, analysis and computational skills: fluorescence image analysis, infrared spectra data analysis, particle tracking algorithm; univariate and multivariate statistical analysis; chemometrics, deep learning, machine learning; proficient in Python, Matlab, Java and R.
Biochemistry and cell biology techniques: extensive primary and cell line tissue culture techniques; protein enzymatic assays, protein fractionation, protein immunoprecipitation, recombinant DNA synthesis, western blot, 2-D gel protein electrophoresis analysis; viral infection system construction, viral particle packaging and infection of primary neurons and cells; transient cell transfection and stable cell transformation are desirable.
Histological techniques: mouse brain and spinal dissection; immunohistochemical analysis of in vitro cultured primary neurons and cell lines are desirable.
Molecular biology techniques: DNA analysis (plasmid extraction, expression vector construction); molecular cloning, sequencing, site-directed mutagenesis; quantitative PCR are desirable.
Teaching/training skills: Proven ability to communicate and train non-expert research staff to prepare live cell samples for infrared spectroscopy perform synchrotron radiation-based Fourier transform infrared spectroscopy (SR-FTIR) measurements and using the in-house software packages (Python and Matlab) to perform spectral data processing, visualization and analysis.
The posting shall remain open until the position is filled.
This is a full-time career appointment.
Full-time, M-F, exempt (monthly paid) from overtime pay.
Salary is commensurate with experience.
This position may be subject to a background check. Any convictions will be evaluated to determine if they directly relate to the responsibilities and requirements of the position. Having a conviction history will not automatically disqualify an applicant from being considered for employment.
Work will be primarily performed at Lawrence Berkeley National Lab, 1 Cyclotron Road, Berkeley, CA.
Berkeley Lab (LBNL) addresses the world's most urgent scientific challenges by advancing sustainable energy, protecting human health, creating new materials, and revealing the origin and fate of the universe. Founded in 1931, Berkeley Lab's scientific expertise has been recognized with 13 Nobel prizes. The University of California manages Berkeley Lab for the U.S. Department of Energy's Office of Science.
Equal Employment Opportunity: Berkeley Lab is an Equal Opportunity/Affirmative Action Employer. All qualified applicants will receive consideration for employment without regard to race, color, religion, sex, sexual orientation, gender identity, national origin, disability, age, or protected veteran status. Berkeley Lab is in compliance with the Pay Transparency Nondiscrimination Provision under 41 CFR 60-1.4. Click here to view the poster and supplement: "Equal Employment Opportunity is the Law."
Internal Number: 86900
About Lawrence Berkeley National Laboratory
In the world of science, Lawrence Berkeley National Laboratory (Berkeley Lab) is synonymous with excellence. Thirteen scientists associated with Berkeley Lab have won the Nobel Prize. Fifty-seven Lab scientists are members of the National Academy of Sciences (NAS), one of the highest honors for a scientist in the United States. Thirteen of our scientists have won the National Medal of Science, our nation's highest award for lifetime achievement in fields of scientific research. Eighteen of our engineers have been elected to the National Academy of Engineering, and three of our scientists have been elected into the Institute of Medicine. In addition, Berkeley Lab has trained thousands of university science and engineering students who are advancing technological innovations across the nation and around the world. Berkeley Lab is a member of the national laboratory system supported by the U.S. Department of Energy through its Office of Science. It is managed by the University of California (UC) and is charged with conducting unclassified research across a wide range of scientific disciplines. Located on a 200-acre site in the hills above the UC Berkeley campus that offers spectacular... views of the San Francisco Bay, Berkeley Lab employs approximately 4,200 scientists, engineers, support staff and students. Its budget for 2011 is $735 million, with an additional $101 million in funding from the American Recovery and Reinvestment Act, for a total of $836 million. A recent study estimates the Laboratory's overall economic impact through direct, indirect and induced spending on the nine counties that make up the San Francisco Bay Area to be nearly $700 million annually. The Lab was also responsible for creating 5,600 jobs locally and 12,000 nationally. The overall economic impact on the national economy is estimated at $1.6 billion a year. Technologies developed at Berkeley Lab have generated billions of dollars in revenues, and thousands of jobs. Savings as a result of Berkeley Lab developments in lighting and windows, and other energy-efficient technologies, have also been in the billions of dollars. Berkeley Lab was founded in 1931 by Ernest Orlando Lawrence, a UC Berkeley physicist who won the 1939 Nobel Prize in physics for his invention of the cyclotron, a circular particle accelerator that opened the door to high-energy physics. It was Lawrence's belief that scientific research is best done through teams of individuals with different fields of expertise, working together. His teamwork concept is a Berkeley Lab legacy that continues today.