Berkeley Lab's Joint Genome Institute Division has an opening for a Chemical Postdoctoral Scholar. Microbial communities comprise the dominant life form on earth and are critical to promoting plant growth. Increasingly, we are turning to beneficial microbes for sustainable agriculture and production of bioproducts. Secondary metabolites enable critical environmental adaptations and communication within microbiomes. Unfortunately, the biosynthesis and functions of these incredibly diverse metabolites are often poorly understood. You will work as part of a cross-functional team exploring Earth's Secondary Metabolome by mining the >50B genes in IMG to identify novel natural product biosynthesis pathways and then express and characterize the products with a specific focus on high throughput metabolomic characterization. When integrated with novel chemoinformatic algorithms, this creates a closed-loop cycle for systematically mapping biochemical space.
What You Will Do:
Mine genomic databases (e.g. IMG) for novel biosynthetic pathways.
Work with multi-functional team to obtain isolates, express pathways, and perform metabolomic analysis.
Use computational tools to link novel metabolites and pathways.
Analyze and integrate results.
Publish scientific papers in peer-reviewed journals and present findings at seminars and conferences.
Collaborate with other members of the program project research team.
Additional Responsibilities as needed:
Identify and apply effective metabolite extraction approaches.
Develop and apply innovative mass spectrometry based metabolite profiling approaches to characterize novel secondary metabolites.
What is Required:
Ph.D. within the last three years in chemistry, biochemistry, chemical biology, environmental microbiology, plant biology, chemical engineering, bioengineering, or related field.
Extensive experience in microbial genomics esp. bioinformatics analysis of secondary metabolite biosynthetic pathways.
Strong knowledge of natural product biosynthetic pathways.
Experience performing statistical analysis or machine learning.
Moderate level of command line comfort in a Unix-like environment.
Demonstrated ability to interact effectively with technical and scientific staff.
Ability to work independently and in a team environment.
Demonstrated ingenuity in dealing with complex problems.
Demonstrated strength and efficiency in technical writing.
Strong publication record.
Additional Desired Qualifications:
Strong background in analytical instrumentation, preferably mass spectrometry.
Strong background in microbial physiology and metabolism.
Specific training in natural product chemistry or related fields.
Experience in extracting and analyzing secondary metabolites.
The posting shall remain open until the position is filled.
This is a full time, 2 years, postdoctoral appointment with the possibility of renewal based upon satisfactory job performance, continuing availability of funds and ongoing operational needs. You must have less than 3 years paid postdoctoral experience. Salary for Postdoctoral positions depends on years of experience post-degree.
Full-time, M-F, exempt (monthly paid) from overtime pay.
This position is represented by a union for collective bargaining purposes.
Salary will be predetermined based on postdoctoral step rates.
This position may be subject to a background check. Any convictions will be evaluated to determine if they directly relate to the responsibilities and requirements of the position. Having a conviction history will not automatically disqualify an applicant from being considered for employment.
Work will be primarily performed at DOE Joint Genome Institute (JGI) — 2800 Mitchell Dr., Walnut Creek, CA.
Berkeley Lab (LBNL) addresses the world's most urgent scientific challenges by advancing sustainable energy, protecting human health, creating new materials, and revealing the origin and fate of the universe. Founded in 1931, Berkeley Lab's scientific expertise has been recognized with 13 Nobel prizes. The University of California manages Berkeley Lab for the U.S. Department of Energy's Office of Science.
Equal Employment Opportunity: Berkeley Lab is an Equal Opportunity/Affirmative Action Employer. All qualified applicants will receive consideration for employment without regard to race, color, religion, sex, sexual orientation, gender identity, national origin, disability, age, or protected veteran status. Berkeley Lab is in compliance with the Pay Transparency Nondiscrimination Provision under 41 CFR 60-1.4. Click here to view the poster and supplement: "Equal Employment Opportunity is the Law."
Internal Number: 86094
About Lawrence Berkeley National Laboratory
In the world of science, Lawrence Berkeley National Laboratory (Berkeley Lab) is synonymous with excellence. Thirteen scientists associated with Berkeley Lab have won the Nobel Prize. Fifty-seven Lab scientists are members of the National Academy of Sciences (NAS), one of the highest honors for a scientist in the United States. Thirteen of our scientists have won the National Medal of Science, our nation's highest award for lifetime achievement in fields of scientific research. Eighteen of our engineers have been elected to the National Academy of Engineering, and three of our scientists have been elected into the Institute of Medicine. In addition, Berkeley Lab has trained thousands of university science and engineering students who are advancing technological innovations across the nation and around the world. Berkeley Lab is a member of the national laboratory system supported by the U.S. Department of Energy through its Office of Science. It is managed by the University of California (UC) and is charged with conducting unclassified research across a wide range of scientific disciplines. Located on a 200-acre site in the hills above the UC Berkeley campus that offers spectacular... views of the San Francisco Bay, Berkeley Lab employs approximately 4,200 scientists, engineers, support staff and students. Its budget for 2011 is $735 million, with an additional $101 million in funding from the American Recovery and Reinvestment Act, for a total of $836 million. A recent study estimates the Laboratory's overall economic impact through direct, indirect and induced spending on the nine counties that make up the San Francisco Bay Area to be nearly $700 million annually. The Lab was also responsible for creating 5,600 jobs locally and 12,000 nationally. The overall economic impact on the national economy is estimated at $1.6 billion a year. Technologies developed at Berkeley Lab have generated billions of dollars in revenues, and thousands of jobs. Savings as a result of Berkeley Lab developments in lighting and windows, and other energy-efficient technologies, have also been in the billions of dollars. Berkeley Lab was founded in 1931 by Ernest Orlando Lawrence, a UC Berkeley physicist who won the 1939 Nobel Prize in physics for his invention of the cyclotron, a circular particle accelerator that opened the door to high-energy physics. It was Lawrence's belief that scientific research is best done through teams of individuals with different fields of expertise, working together. His teamwork concept is a Berkeley Lab legacy that continues today.