Berkeley Lab's Molecular Biophysics & Integrated Bioimaging Division has an opening for a Project Scientist. Under the general direction of the Principal Investigator, the Project Scientist will conceive and develop research directions in the area DNA Repair and genetic instability in neurons. The individual will be expected to take a leadership role in planning and completion of research in the area DNA repair biochemistry and mitochondrial dynamics.
What You Will Do:
Perform biochemical purification and biophysical analysis of protein complexes.
Responsible for purification of ABC-ATPases, the MMR complexes, which includes.
(1) purifying of MSH2/MSH3 and MSH2/MSH6 complexes.
(2) mapping the ATP and ADP subunit occupancy.
(3) measuring the nucleotide binding affinity in each complex.
(4) measuring the rate of ATP hydrolysis on and off DNA.
(5) testing the effects of nucleotides in driving nuclease activity on DNA expansion.
Evaluating mouse models of key mutants and their ability to induce mutation.
Nanoparticle labeling of MT, imaging of its activity, and will independently plan and complete research on mitochondrial metabolism.
Present research at seminars and conferences.
Prepare manuscripts and publish in peer-reviewed journals.
Assist the PI in developing grant proposals.
Independent development of research project with appropriate command of methodology.
Maintain organized and well-documented laboratory notebook.
Direct or formally supervise the work of support staff related to the research. This includes supervision of postdoctoral Fellows, Research Associates, technical support staff, and students relevant to the project.
Responsible and accountable for proper conduct of the project or activity.
What is Required:
Has a minimum of 3 to 5 years of research experience beyond customary highest degree (postdoctoral training may serve as experience).
Command and familiarity with common molecular techniques (gels, protein and DNA detection, etc.)
Background in genetics mechanisms.
Previous experience leading or supervising the work of others.
Has demonstrated technical proficiency in field of biochemistry and molecular biology with sound knowledge of major scientific concepts in the field. For example, may have demonstrated knowledge of or experience in protein purification, binding analysis, and design, construction and use of mutant proteins.
Excellent written and communication skills.
Additional Desired Qualifications:
PhD or equivalent training and experience in one of the following disciplines: Biochemistry, Molecular Biology, or Biophysics.
Have an interest in neuroscience.
Experience with R programming.
The posting shall remain open until the position is filled.
This is a full time, 1 year, term appointment with the possibility of extension or conversion to Career appointment based upon satisfactory job performance, continuing availability of funds and ongoing operational needs.
Full-time, M-F, exempt (monthly paid) from overtime pay.
Salary is commensurate with experience.
This position may be subject to a background check. Any convictions will be evaluated to determine if they directly relate to the responsibilities and requirements of the position. Having a conviction history will not automatically disqualify an applicant from being considered for employment.
Work will primarily be performed at Lawrence Berkeley National Lab, 1 Cyclotron Road, Berkeley, CA.
Berkeley Lab (LBNL) addresses the world's most urgent scientific challenges by advancing sustainable energy, protecting human health, creating new materials, and revealing the origin and fate of the universe. Founded in 1931, Berkeley Lab's scientific expertise has been recognized with 13 Nobel prizes. The University of California manages Berkeley Lab for the U.S. Department of Energy's Office of Science.
Equal Employment Opportunity: Berkeley Lab is an Equal Opportunity/Affirmative Action Employer. All qualified applicants will receive consideration for employment without regard to race, color, religion, sex, sexual orientation, gender identity, national origin, disability, age, or protected veteran status. Berkeley Lab is in compliance with the Pay Transparency Nondiscrimination Provision under 41 CFR 60-1.4. Click here to view the poster and supplement: "Equal Employment Opportunity is the Law."
Internal Number: 85868
About Lawrence Berkeley National Laboratory
In the world of science, Lawrence Berkeley National Laboratory (Berkeley Lab) is synonymous with excellence. Thirteen scientists associated with Berkeley Lab have won the Nobel Prize. Fifty-seven Lab scientists are members of the National Academy of Sciences (NAS), one of the highest honors for a scientist in the United States. Thirteen of our scientists have won the National Medal of Science, our nation's highest award for lifetime achievement in fields of scientific research. Eighteen of our engineers have been elected to the National Academy of Engineering, and three of our scientists have been elected into the Institute of Medicine. In addition, Berkeley Lab has trained thousands of university science and engineering students who are advancing technological innovations across the nation and around the world. Berkeley Lab is a member of the national laboratory system supported by the U.S. Department of Energy through its Office of Science. It is managed by the University of California (UC) and is charged with conducting unclassified research across a wide range of scientific disciplines. Located on a 200-acre site in the hills above the UC Berkeley campus that offers spectacular... views of the San Francisco Bay, Berkeley Lab employs approximately 4,200 scientists, engineers, support staff and students. Its budget for 2011 is $735 million, with an additional $101 million in funding from the American Recovery and Reinvestment Act, for a total of $836 million. A recent study estimates the Laboratory's overall economic impact through direct, indirect and induced spending on the nine counties that make up the San Francisco Bay Area to be nearly $700 million annually. The Lab was also responsible for creating 5,600 jobs locally and 12,000 nationally. The overall economic impact on the national economy is estimated at $1.6 billion a year. Technologies developed at Berkeley Lab have generated billions of dollars in revenues, and thousands of jobs. Savings as a result of Berkeley Lab developments in lighting and windows, and other energy-efficient technologies, have also been in the billions of dollars. Berkeley Lab was founded in 1931 by Ernest Orlando Lawrence, a UC Berkeley physicist who won the 1939 Nobel Prize in physics for his invention of the cyclotron, a circular particle accelerator that opened the door to high-energy physics. It was Lawrence's belief that scientific research is best done through teams of individuals with different fields of expertise, working together. His teamwork concept is a Berkeley Lab legacy that continues today.