The DOE Joint Genome Institute (JGI) in Walnut Creek, CA (a division of the Lawrence Berkeley National Lab) has an exciting opportunity available for a Synthetic Biology Project Scientist. We are looking for a talented, highly motivated candidate with a strong background in molecular biology and bacterial and fungal strain engineering to join the Synthetic Biology Platform Group. The successful candidate will be expected to design and build biosynthesis gene clusters and express them in a series of domesticated bacteria strains using a newly developed strain engineering technology. This position will lead the development and implementation of new strategies for host strain engineering. The candidate will be expected to work independently, as well as contribute as a member of a dynamic, multidisciplinary team of biologists, process automation engineers, and software developers. Will report to the Functional Genomics Group Lead.
Notes: This is a one-year term appointment with the possibility of renewal based upon satisfactory job performance, continuing availability of funds, and ongoing operational needs. Work will be performed at the DOE Joint Genome Institute (JGI) in Walnut Creek, CA. The job may require occasional travel, weekend, and after-hours work. Detailed information about the Joint Genome Institute program can be found at http://www.jgi.doe.gov.
What You Will Do:
Responsible for designing and assembling large gene clusters into appropriate vectors for conjugation and heterologous expression in a set of domesticated bacteria.
Continue to develop robust strain engineering technologies to successfully engineer a wide range of bacterial hosts.
Perform research and development to improve and automate various aspects of host strain engineering processes.
Collaborate closely with the Sequencing Technologies and Metabolomics groups to perform high-throughput functional characterization of engineered microbes.
Troubleshoot all stages of experimental processes and optimize Standard Operating Procedures (SOP).
Provide intellectual and technological leadership to facilitate collaborative strain engineering user projects.
Present updates at group meetings and at scientific conferences, and publish results in peer-reviewed journals.
Additional Responsibilities as needed:
Mentor and train technical staff and other group members as necessary.
Participate in the development and preparation of grant proposals for new or extended research directions.
What is Required:
Ph.D. and or equivalent experience in microbiology, molecular biology, biochemistry or a related discipline.
Demonstrated experience with advanced molecular cloning of large DNA constructs using yeast homologous recombination and Golden Gate methods.
Substantial experience in the methodology of introducing DNA into a wide range of bacterial and fungal cells.
Experienced in the cultivation of a wide range of bacteria and fungi at multiple scales
Effective problem-solving and decision-making skills with the ability to troubleshoot experimental processes and provide analysis.
Extensive experience in synthetic biology design principles and applications of design tools.
Strong organizational, analytical, and record-keeping skills with the ability to organize and present technical reports to collaborators, JGI staff, management, and sponsors
Demonstrated effectiveness in conducting collaborative research in a team environment with diverse skills and expertise.
Excellent written and oral communication skills.
Additional Desired Qualifications:
Experience with other functional genomics technologies including CRISPR/Cas9, proteomics, and metabolomics.
Experience in or familiarity with automated liquid handling systems.
The posting shall remain open until the position is filled.
This is a full time, 1 year, term appointment with the possibility of extension or conversion to Career appointment based upon satisfactory job performance, continuing availability of funds and ongoing operational needs.
Full-time, M-F, exempt (monthly paid) from overtime pay.
Salary is commensurate with experience.
This position may be subject to a background check. Any convictions will be evaluated to determine if they directly relate to the responsibilities and requirements of the position. Having a conviction history will not automatically disqualify an applicant from being considered for employment.
Work will be primarily performed at DOE Joint Genome Institute (JGI) — 2800 Mitchell Dr., Walnut Creek, CA.
Berkeley Lab (LBNL) addresses the world's most urgent scientific challenges by advancing sustainable energy, protecting human health, creating new materials, and revealing the origin and fate of the universe. Founded in 1931, Berkeley Lab's scientific expertise has been recognized with 13 Nobel prizes. The University of California manages Berkeley Lab for the U.S. Department of Energy's Office of Science.
Equal Employment Opportunity: Berkeley Lab is an Equal Opportunity/Affirmative Action Employer. All qualified applicants will receive consideration for employment without regard to race, color, religion, sex, sexual orientation, gender identity, national origin, disability, age, or protected veteran status. Berkeley Lab is in compliance with the Pay Transparency Nondiscrimination Provision under 41 CFR 60-1.4. Click here to view the poster and supplement: "Equal Employment Opportunity is the Law."
Internal Number: 85761
About Lawrence Berkeley National Laboratory
In the world of science, Lawrence Berkeley National Laboratory (Berkeley Lab) is synonymous with excellence. Thirteen scientists associated with Berkeley Lab have won the Nobel Prize. Fifty-seven Lab scientists are members of the National Academy of Sciences (NAS), one of the highest honors for a scientist in the United States. Thirteen of our scientists have won the National Medal of Science, our nation's highest award for lifetime achievement in fields of scientific research. Eighteen of our engineers have been elected to the National Academy of Engineering, and three of our scientists have been elected into the Institute of Medicine. In addition, Berkeley Lab has trained thousands of university science and engineering students who are advancing technological innovations across the nation and around the world. Berkeley Lab is a member of the national laboratory system supported by the U.S. Department of Energy through its Office of Science. It is managed by the University of California (UC) and is charged with conducting unclassified research across a wide range of scientific disciplines. Located on a 200-acre site in the hills above the UC Berkeley campus that offers spectacular... views of the San Francisco Bay, Berkeley Lab employs approximately 4,200 scientists, engineers, support staff and students. Its budget for 2011 is $735 million, with an additional $101 million in funding from the American Recovery and Reinvestment Act, for a total of $836 million. A recent study estimates the Laboratory's overall economic impact through direct, indirect and induced spending on the nine counties that make up the San Francisco Bay Area to be nearly $700 million annually. The Lab was also responsible for creating 5,600 jobs locally and 12,000 nationally. The overall economic impact on the national economy is estimated at $1.6 billion a year. Technologies developed at Berkeley Lab have generated billions of dollars in revenues, and thousands of jobs. Savings as a result of Berkeley Lab developments in lighting and windows, and other energy-efficient technologies, have also been in the billions of dollars. Berkeley Lab was founded in 1931 by Ernest Orlando Lawrence, a UC Berkeley physicist who won the 1939 Nobel Prize in physics for his invention of the cyclotron, a circular particle accelerator that opened the door to high-energy physics. It was Lawrence's belief that scientific research is best done through teams of individuals with different fields of expertise, working together. His teamwork concept is a Berkeley Lab legacy that continues today.