Berkeley Lab's Biological Systems and Engineering Division has an opening for a Computational Biological Research Scientist. The candidate will leverage machine learning, synthetic biology and automation to make bioengineering a predictable endeavor, for the production ofcommercially viable bioproducts and other purposes. This position will be part of theQuantitative Modeling Group. Under general supervision of the principal investigator, the candidate will work as part of a collaborative team to integrate phenotypic data (e.g. fluxomics, transcriptomics, proteomics, metabolomics) into quantitative computational models able to predict the outcome of bioengineering approaches, as well as develop and apply automation solutions to gather these data. The candidate will be working closely with bench scientists, automation engineers and software developers in devising methods for high-throughput data collection and analysis for feedback into experimental design, as part of theJoint BioEnergy Institute, theAgile BioFoundry, or other programs.
What You Will Do:
Develop quantitative predictive models of cell metabolism.
Integrate transcriptomic, proteomic and metabolomic data into quantitative models.
Use machine-learning approaches to predict bioengineering outcomes.
Develop and validate kinetic models for microbial metabolism.
Develop and optimize code and algorithms for predictive models.
Interact continuously with bench scientists to guide and propose new experiments and use available data to its full potential.
Prepare research results for publication and for presentations at scientific and internal meetings.
Develop automated experiments in collaboration with automation engineers to gather data for predictive models.
Perform advanced molecular biology protocols (e.g. construct design, gene knockout, cloning and expression) in order to test methods to be automated.
Conduct projects independently, maintain appropriate records and manage data.
Provide oversight and direction for a team of students, post-doctoral fellows and research associates.
Participate in group meetings, steering committee meetings, project retreats and seminars.
Assist in preparation of grant proposals.
What is Required:
PhD in systems biology, bioengineering, computational biology, bioinformatics, applied mathematics, theoretical physics, computer science, electrical engineering or closely related discipline.; or equivalent experience.
Significant experience in python or other major programming language.
Strong mathematical background and analytical skills.
Experience in Machine Learning.
Strong interest in microbiology and bacterial metabolism.
Strong written communication skills.
A commitment to and demonstrated ability to perform collaborative research in an interdisciplinary team environment.
Experience in lab automation (e.g. liquid handlers).
Experience in experimental metabolic engineering bench work (e.g. construct design, gene knockout, cloning, and expression).
Additional Desired Qualifications:
Experience in Deep Learning techniques
Knowledge of microbiology and bacterial metabolism.
Experience in metabolic flux analysis.
Knowledge of control theory.
The posting shall remain open until the position is filled, however for full consideration, please apply by close of business on November 2, 2018.
This is a full time, 1 year, career-track term appointment that may be renewed to a maximum of five years and that may be converted to career based upon satisfactory job performance, continuing availability of funds, and ongoing operational needs.
Full-time, M-F, exempt (monthly paid) from overtime pay.
Salary is commensurate with experience.
This position may be subject to a background check. Any convictions will be evaluated to determine if they directly relate to the responsibilities and requirements of the position. Having a conviction history will not automatically disqualify an applicant from being considered for employment.
Work will be primarily performed at Joint BioEnergy Institute (JBEI) — Bldg. 978, 5885 Hollis St., 4th floor, Emeryville, CA.
Berkeley Lab (LBNL) addresses the world's most urgent scientific challenges by advancing sustainable energy, protecting human health, creating new materials, and revealing the origin and fate of the universe. Founded in 1931, Berkeley Lab's scientific expertise has been recognized with 13 Nobel prizes. The University of California manages Berkeley Lab for the U.S. Department of Energy's Office of Science.
Equal Employment Opportunity: Berkeley Lab is an Equal Opportunity/Affirmative Action Employer. All qualified applicants will receive consideration for employment without regard to race, color, religion, sex, sexual orientation, gender identity, national origin, disability, age, or protected veteran status. Berkeley Lab is in compliance with the Pay Transparency Nondiscrimination Provision under 41 CFR 60-1.4. Click here to view the poster and supplement: "Equal Employment Opportunity is the Law."
Internal Number: 85711
About Lawrence Berkeley National Laboratory
In the world of science, Lawrence Berkeley National Laboratory (Berkeley Lab) is synonymous with excellence. Thirteen scientists associated with Berkeley Lab have won the Nobel Prize. Fifty-seven Lab scientists are members of the National Academy of Sciences (NAS), one of the highest honors for a scientist in the United States. Thirteen of our scientists have won the National Medal of Science, our nation's highest award for lifetime achievement in fields of scientific research. Eighteen of our engineers have been elected to the National Academy of Engineering, and three of our scientists have been elected into the Institute of Medicine. In addition, Berkeley Lab has trained thousands of university science and engineering students who are advancing technological innovations across the nation and around the world. Berkeley Lab is a member of the national laboratory system supported by the U.S. Department of Energy through its Office of Science. It is managed by the University of California (UC) and is charged with conducting unclassified research across a wide range of scientific disciplines. Located on a 200-acre site in the hills above the UC Berkeley campus that offers spectacular... views of the San Francisco Bay, Berkeley Lab employs approximately 4,200 scientists, engineers, support staff and students. Its budget for 2011 is $735 million, with an additional $101 million in funding from the American Recovery and Reinvestment Act, for a total of $836 million. A recent study estimates the Laboratory's overall economic impact through direct, indirect and induced spending on the nine counties that make up the San Francisco Bay Area to be nearly $700 million annually. The Lab was also responsible for creating 5,600 jobs locally and 12,000 nationally. The overall economic impact on the national economy is estimated at $1.6 billion a year. Technologies developed at Berkeley Lab have generated billions of dollars in revenues, and thousands of jobs. Savings as a result of Berkeley Lab developments in lighting and windows, and other energy-efficient technologies, have also been in the billions of dollars. Berkeley Lab was founded in 1931 by Ernest Orlando Lawrence, a UC Berkeley physicist who won the 1939 Nobel Prize in physics for his invention of the cyclotron, a circular particle accelerator that opened the door to high-energy physics. It was Lawrence's belief that scientific research is best done through teams of individuals with different fields of expertise, working together. His teamwork concept is a Berkeley Lab legacy that continues today.